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KMID : 0043320110340020199
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Archives of Pharmacal Research
2011 Volume.34 No. 2 p.199 ~ p.202
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Two new monoterpene alkaloid derivatives from the roots of Incarvillea arguta
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Fu Jian Jun
Qin Jiang Jiang
Zeng Qi
Huang Ying
Zhang Wei Dong
Jin Hui Zi
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Abstract
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Two new monoterpene alkaloid derivatives, incargutosines C (1) and D (2), together with a known compound, argutine A (3) have been isolated from the roots of Incarvillea arguta Royle. The structures of 1 and 2 were established on the basis of 1D and 2D NMR spectroscopic analysis, while the absolute configurations of 1 and 2 were determined by a synthetic method. In addition, the cytotoxicity of 3 was evaluated using four tumor cell lines, A549, LOVO, 6TCEM, and MDA-MB-435 (MDA) by the MTT assay.
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KEYWORD
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Incarvillea arguta, Monoterpene alkaloid, Incargutosine C, Incargutosine D, Cytotoxicity
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